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Image Search Results
Journal: Neurobiology of disease
Article Title: APC conditional knock-out mouse is a model of infantile spasms with elevated neuronal β-catenin levels, neonatal spasms, and chronic seizures
doi: 10.1016/j.nbd.2016.11.002
Figure Lengend Snippet: (A) Example EEG recording from P9 WT mouse showing little to no high amplitude activity. (Inset) Increased time scale of (A) at time 1. (B) Example EEG recording from P9 APC cKO animal showing multiple high amplitude EEG events. (Inset) Increased time scale of (B) at times 1 and 2. Note: Both (1) simple high amplitude spikes and (2) more complex high amplitude spikes followed by continued disruption of the EEG occur in APC cKO animals. (C) Image of a P12 mouse implanted with a radio-telemetry based EEG head mount. (D) Quantification of the frequency of high amplitude discharges in WT and APC cKO mice (*** p<0.001, 2 way ANOVA, WT: P9, n=3, P10, n=6, P11, n=6, P12, n=6; cKO: P9, n=3, P10, n=4, P11, n=6, P12, n=6). The peak of aberrant EEG activity at P9 matches the time frame of the peak in behavioral spasm intensity.
Article Snippet: Neonatal EEG Neonatal mice (P8, 9, or 10; based on minimal animal weight required to perform surgery) were anesthetized with isoflurane, surgically implanted with a custom made
Techniques: Activity Assay, Disruption